کلوئید غیر سمی پلی‌کاپرولاکتون برای نانوکپسوله کردن جنیستین از طریق روش کوآسرواسیون و الکترواسپینینگ در داربست آبدوست
  •   آرشیو : نسخه بهار و تابستان 1403
  •   کد پذیرش : 1253
  •   موضوع : سایر شاخه ها
  • نویسنده/گان : | سکینه اسماعیل نیا، راهبه امیری دهخوارقانی، سهیلا زمانلوی بنیسی
  •   زبان : فارسی
  •   نوع مقاله : پژوهشی
  •   چکیده مقاله به فارسی : در این تحقیق، بستر زیست‌سازگار حاوی ماده موثره گیاهی به منظور بهبود تکثیر و رفتار سلولی در شرایط آزمایشگاهی برای کاربردهای مهندسی بافت در پزشکی طراحی شده‌اند. در این راستا، جنیستین از کنجاله سویا استخراج و با استفاده از پلی کاپرولاکتون (PCL) از طریق روش کوآسرواسیون (coacervation) نانوکپسوله شد. در نهایت، نانوالیافی زیست‌سازگار ژلاتین (GE) و پلی وینیل الکل(PVA) با ترکیب نانوکپسول‌های جنیستین از طریق روش الکتروریسی سنتز گردیدند. آزمایشات با استفاده از کروماتوگرافی مایع با کارایی بالا (HPLC)، طیف‌سنج مرئی فرابنفش (UV-Vis)، میکروسکوپ الکترونی روبشی(SEM)، میکروسکوپ الکترونی عبوری (TEM)، طیف‌سنج مادون قرمز تبدیل فوریه (FTIR) و آزمون مکانیکی انجام شد. تأثیرات بیولوژیکی و زنده‌مانی سلول بر روی داربست جنیستین محصور شده با روش MTT بررسی شد. عدم سمیت نمونه سنتز شده با تکثیر و چسبندگی قابل توجه روی رده سلولی L929 به دست آمد. نتیجه‌گیری نشان داد که سیستم زیست‌سازگار توصیف شده می‌تواند به عنوان یک ابزار هوشمند رهاسازی دارو در شرایط آزمایشگاهی برای مهندسی بافت مورد استفاده قرار گیرد.
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  •   کلمات کلیدی به فارسی : پلی کاپرولاکتون، جنیستین، نانوکپسول، الکتروریسی، کوآسرواسیون، رده سلولی L929.
  •   چکیده مقاله به انگلیسی :
  •   کلمات کلیدی به انگلیسی :
  •  صفحات : 12-26
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